Seed financed by Sofinnova Partners, Bionyra was co-founded by Sofinnova Partners and Frédéric Marrache, MD, PhD, MBA. Prior to joining Bionyra, Frédéric served as Vice President for Clinical Development in the Immunology and Inflammation Therapeutic Area at Sanofi where he led a portfolio of drug development programs focused on immune-mediated diseases. The company is committed to overcoming the limitations of existing therapies by delivering patient-optimized treatments with greater efficacy and improved convenience, offering better and longer-lasting outcomes.
Severe immune-mediated inflammatory diseases impose a constant toll as patients live with a high daily burden of pain, fatigue and uncertainty, structuring their lives around flares, hospital visits and treatment setbacks. Current therapies often target single nodes of complex immune networks, limiting depth and durability of response. Many patients cycle through multiple therapies without achieving sustained relief or meaningful improvements in quality of life, highlighting the need for better therapeutic options that can improve clinical outcomes.
Bionyra is launching with a broad pipeline of clinical and near-clinical, next-generation anti-inflammatory therapies designed to deliver first- and best-in-class treatments by combining targeted biology with optimized pharmacokinetics, including:
BYN-002
A leading TL1A monoclonal antibody with half-life extension (HLE) technology with best-in-class potential in IBD and other TL1A-relevant indications. A Phase 1 study in healthy subjects is fully enrolled. TL1A is a cytokine that drives chronic inflammation, tissue damage and fibrosis in immune-driven diseases, including IBD and other immune-mediated conditions. BYN-002 was designed to minimize dosing frequency and offers a significant opportunity to impact patient outcomes.
BYN-003
A first and best-in-class TL1A*IL-23p19 bispecific monoclonal antibody with HLE technology with a Phase 1 study now underway. Targeting both TL1A and IL-23 through a bispecific antibody (a single molecule that targets both signals at the same time) can offer a more efficient way to dial down multiple drivers of disease.
BYN-001
A first and best-in-class IL-25 monoclonal antibody with half-life extension (HLE) technology in a Phase 1 study for atopic dermatitis and Type 2 inflammation. IL-25 is a key pathogenic alarmin that drives Type 2 inflammation beyond downstream effector cytokines like IL-4 and IL-13. Blocking IL-25 has been shown to reduce inflammation and helps restore immune balance.
The company licensed BYN-002 and BYN-003 from TrueLab Biopharmaceutical and BYN-001 from NovaRock Biotherapeutics and holds exclusive global rights outside of Greater China. In addition, Bionyra is progressing additional innovative preclinical assets, including some from TrueLab.
Bionyra’s oversubscribed Series A financing was co-led by Jeito Capital and Sofinnova Partners. Arkin Bio, Sanofi Ventures, Sixty Degree Capital, Vives Partners and Apollo Health Ventures also participated in this inaugural funding. 
Bionyra launches with $165m, France’s largest biotech Series A
With an unusually strong fundraising trajectory, Paris-based Bionyra Pharma emerged from stealth today with financing that marks the largest life sciences biopharma Series A round in Europe this year and the largest of all time in France. The company develops next-generation biologics for immune-mediated inflammatory diseases, including inflammatory bowel disease (IBD) and atopic dermatitis. The […]
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Bionyra’s $165M launch: A Sanofi alum, I&I candidates from China, one big catch-up
A former Sanofi I&I development executive has brought together a who’s who of investors and assembled three drug candidates from Chinese and US biotechs after scanning about 100 global assets. Frédéric Marrache, who spent much of the past decade at the French pharma leading clinical work on immunology and inflammation, has collected $165 million as […]
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Helmed by Sanofi vet, Bionyra emerges with $165M and three licensed I&I assets
For Bionyra Pharma co-founder and CEO Frédéric Marrache, M.D., Ph.D., “the planets had to align” to pull him out of his R&D VP role at Sanofi. But after weighing the opportunity to lead immunology and inflammation (I&I) biotech, he decided to take the jump and scratch the entrepreneurial itch he had been feeling for years. […]
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